Drug Standards
Apexbio Technology LLC Lumateperone tosylate 1187020-80-9 10mg
Lumateperone tosylate (CAS 1187020-80-9) is a small molecule characterized as a selective antagonist of the 5-HT2A receptor (Ki 0 54 nM) It exhibits partial agonist activity at presynaptic dopamine D2 receptors and antagonist action at postsynaptic D2 receptors (Ki 32 nM) while also modulating dopamine D1 receptor function Preclinical studies indicate that lumateperone tosylate influences neurotransmitter release and synaptic signaling pathways It is utilized in research investigating the pathophysiology and treatment of neuropsychiatric disorders such as schizophrenia as well as in studies exploring its potential anticancer properties
TARGETMOL CHEMICALS INC Metoclopramide 500MG
Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. Purity 99.81%
Medchemexpress LLC Tenofovir amibufenamide | 1571076-26-0 | 99.7% | 490.49 | 5 MG
Tenofovir amibufenamide is a Tenofovir prodrug and an orally active antiviral agent. It inhibits HBV and is used for chronic hepatitis B (CHB) studies.
- Inhibits HBV DNA replication in HepG2.2.15 cells (EC50 of 7.3 nM).
- Corrects metabolic disorders in host liver cells caused by HBV infection.
- Regulates hepatocyte metabolism in HBV transgenic mice.
- Decreases HBV DNA levels in serum in HBV transgenic mice.
Apexbio Technology LLC Milrinone 78415-72-2 10mM (in 1mL DMSO)
Milrinone (CAS 78415-72-2) is a selective inhibitor of phosphodiesterase 3 (PDE3) demonstrating an IC50 of 56 12 nM for PDE3 inhibition It acts on both PDE3A localized predominantly in cardiac tissue vascular smooth muscle and platelets and PDE3B found in adipose tissue liver and pancreatic islets Milrinone increases intracellular cAMP levels in platelets with an EC50 of 5329 970 nM leading to enhanced contractility and vasodilation effects This profile supports its utility in cardiovascular research and metabolic studies involving cAMP-mediated signaling pathways
Selleck Chemical LLC Plerixafor (AMD3100) 8HCl 50mg 155148-31-5 JM 3100 8HCl
Plerixafor (AMD3100, JM 3100) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Tenofovir Alafenamide
Tenofovir Alafenamide is a prodrug of tenofovir which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B
Selleck Chemical LLC Heparin sodium 200mg 9041-08-1
Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Efavirenz 100mg 154598-52-4 Sustiva, Stocrin, DMP-266, DMP 266
Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Desogestrel 54024-22-5 10mM (in 1mL DMSO)
Desogestrel (CAS 54024-22-5) is a synthetic progestogen derivative targeting the progesterone receptor It is designed to selectively activate this receptor thereby suppressing gonadotropin secretion and inhibiting ovarian follicle maturation and ovulation Desogestrel exerts its biological activity primarily through selective activation of progesterone receptors Based on its chemical structure desogestrel contains an alkyne functional group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules Based on these pharmacological properties desogestrel holds research potential in targeted drug modification probe labeling and pharmacological investigations as well as serving as an active ingredient in oral contraceptive formulations